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Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model


Adi Morany


Abstract:

The aortic valve (AV) is located between the left ventricle and the aorta and responsible for maintaining an outward unidirectional flow. Many AV hemodynamic and structural aspects of have been extensively studied, however, more sophisticated models are needed to better understand the AV biomechanical behavior. This study deals with integrating a new parametric AV structural model with the electro-mechanical Living Heart Human Model® (LHHM). The LHHM is a finite element model simulating human heart capable of realistic electro-mechanical simulations. Different geometric metrics of AV have been examined. New integrated structural AV model within the LHHM better predict local stresses during the cardiac cycle due to the realistic boundary condition derived from the LHHM. It was found that ellipticity index (EI), calculated as the ratio between the maximal (Max) and minimal (Min) aortic annulus (AA) diameters, well correlates with measured clinical data obtained from patients undergoing computed tomography (CT) while the annular perimeter (Perim) matches the same trend. This increases the confidence in the predicted kinematic behavior, leaflets coaptation, and the overall stresses. From the clinical aspect, the new proposed coupled and integrated AV modeling can serve as a platform for design and implementation of pre-transcatheter aortic valve replacement (TAVR) procedures.


Representative Results:



Paper Publication


Education

03/2019-02/2024:  Ph.D. in Mechanical Engineering

Mechanical Engineering School, Engineering Faculty, Tel Aviv University 

10/2016-12/2018: M.Sc. in Mechanical Engineering (Magna Cum Laude)

Mechanical Engineering School, Engineering Faculty, Tel Aviv University 

10/2010-04/2015:  B.Sc. in Aerospace Engineering

Faculty of Aerospace Engineering, Technion – Israel Institute of Technology, Haifa


Research Experience

Biomechanics of healthy and diseased aortic valve manners. 

Electromechanical simulation of full heart model.

Computational simulations of structural FEA, CFD 

Fluid-structure interaction (FSI) modeling approach for coupled FE structural analysis with Lattice Boltzmann Method (LBM)

Medical devices simulation; TAVR etc.

Calcific and fibrocalcific aortic valve disease progression; clinical and biomechanical modelling.

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